Cannabics Pharmaceuticals Study Shows Cannabinoids CBNA and CBCA Cause Necrosis Similarly to their Non-acidic Form

TEL AVIV, Israel and BETHESDA, Maryland, Feb. 18, 2020 /PRNewswire/ — Cannabics Pharmaceuticals Inc. (OTCQB: CNBX), a leader in personalized cannabinoid medicine focused on cancer and its side effects, announced today that the cannabinoids CBN (Cannabinol) and CBC (Cannabichromene) and their acidic form were shown to have necrotic effects on human colon cancer cells in a pre-clinical study held at the company’s High Throughput Screening (HTS) facility in Israel.

Necrotic effect of CBN on Colon Cancer: Nuclear (Blue) and Necrosis (Yellow) dyes were analyzed using fluorescent microscopy. Left: Untreated cells. Right: Cells treated with CBN.

CBN is a mildly psychoactive cannabinoid found only in trace amounts in Cannabis. Degraded or oxidized cannabis oils have high CBN concentration. CBN is the degraded product of Tetrahydrocannabinolic acid (THCA). THCA will convert to Cannabinolic acid (CBNA) when exposed to air or ultraviolet light for a prolonged period of time. CBN is then formed by decarboxylation of CBNA.

The findings obtained at the lab are complementary to our previous results, indicating that some cannabinoids are more toxic to cancer cells in their carboxylated form and some in their acidic form.

The company continues to screen cannabinoid compound libraries at the HTS facility in Israel, whilst seeking to create proprietary formulations targeting cancers.

Dr. Ilan Hochman, the company’s VP of R&D: “Cannabinoids have various biological pathways which are revealed by many scientific studies. The current results add to the complexity of our observations justifying solid preclinical science as a major step before clinical validation.”

About Cannabics Pharmaceuticals

Cannabics Pharmaceuticals Inc. (OTCQB: CNBX) is a U.S. public company that is developing a platform which leverages novel drug-screening tools and artificial intelligence to create cannabinoid-based therapies for cancer that are more precise to a patient’s profile. By developing tools to assess effectiveness on a personalized basis, Cannabics is helping to move cannabinoids into the future of cancer therapy. The company’s R&D is based in Israel, where it is licensed by the Ministry of Health to conduct scientific and clinical research on cannabinoid formulations and Cancer. For more information, please visit

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